Bupropion-Naltrexone (Contrave)

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Bupropion-Naltrexone (Contrave)

An FDA-approved oral weight-care combination for adults who aren't GLP-1 candidates.

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Overview

Contrave combines a norepinephrine-dopamine reuptake inhibitor (bupropion) with an opioid antagonist (naltrexone) to modulate hunger and reward pathways in the brain. Used in weight care for non-GLP-1 candidates.

Ingredients

Bupropion HCl; naltrexone HCl

Use & directions

Combination oral tablet titrated over 4 weeks per FDA-approved protocol.

Important information.

Side effects

Common: nausea, constipation, headache, insomnia, dry mouth. Rare: seizures, hepatotoxicity.

Safety & precautions

Important Safety Information — Boxed Warning. Bupropion carries a suicidality warning in young adults. Not for patients with seizure disorders, uncontrolled hypertension, or opioid use.

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